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罗凌飞 博士,男,生于1977年11月。国家自然科学基金委员会生命科学部第六、七届专家咨询委员会委员(2014-2020)、第九届国家杰出青年科学基金评审委员会委员(2018-2020);国家杰出青年科学基金获得者(2009)、国家级人才计划入选者(2013、2019)、国家“973计划”项目首席科学家(2008、2014)、中国青年五四奖章获得者(2013)、国务院特殊津贴获得者(2019)、教育部创新团队带头人(2008、2013)、“脊椎动物器官发育与再生”****基地负责人(2013、2018)。现任中国细胞生物学学会副理事长、中国遗传学会发育遗传专业委员会委员、重庆市细胞生物学会理事长。实验室以斑马鱼和小鼠为主要模式动物,以消化器官和脑血管的发育与再生为主要研究方向。研究成果先后发表在Nature、Immunity、Gastroenterology、Developmental Cell、Hepatology、Cell Reports等著名期刊上。曾获得德国蔡司斑马鱼科学研究优秀青年学者奖(2016)、第六届“中国侨界贡献奖-创新团队奖”(团队负责人,2016)、第五届“中国侨界贡献奖-创新人才奖”(2014)、重庆市自然科学奖一等奖(排名第一,2011)、德国马普协会主席-副主席奖创新奖(Gruss-Jäckle Prize, Innovation Prize,2003)。
研究方向:
实验室以斑马鱼和小鼠为主要模式动物,以消化器官及脑血管发育与再生为主要研究方向:
1)早期内胚层的发育谱系及命运决定机制研究;
2)消化器官发育和再生的细胞和分子调控机制研究;
3)脑血管再生的细胞和分子调控机制研究。
代表性SCI学术论文:
1)Xianding Sun, Yang Zhou, Ruobin Zhang, Zuqiang Wang, Meng Xu, Dali Zhang, Junlan Huang, Fengtao Luo, Fangfang Li, Zhenhong Ni, Siru Zhou, Hangang Chen, Shuai Chen, Liang Chen, Xiaolan Du, Bo Chen, Haiyang Huang, Peng Liu, Liangjun Yin, Juhui Qiu, Di Chen, Chuxia Deng, Yangli Xie*, Lingfei Luo*, Lin Chen*. (2020). Nature Communications 11, 479. (IF 11.9)
2)Jiaobo He, Jingying Chen, Xiangyong Wei, Hui Leng, Hongliang Mu, Pengcheng Cai,Lingfei Luo*. (2019). Mammalian Target of Rapamycin Complex 1 Signaling Is Required for the Dedifferentiation From Biliary Cell to Bipotential Progenitor Cell in Zebrafish Liver Regeneration. Hepatology 70(6), 2092–2106. (IF 15.0,封面文章)
3)Jingying Chen, Jianbo He, Rui Ni, Qifen Yang, Yaoguang Zhang, Lingfei Luo*. (2019). Cerebrovascular injuries induce lymphatic invasion into brain parenchyma to guide vascular regeneration in zebrafish. Developmental Cell 49(5), 697–710. (IF: 9.2,封面文章)
4)Zigang Cao, Xiaoyu Mao, Lingfei Luo*. (2019). Germline stem cells drive ovary regeneration in zebrafish. Cell Reports 26(7), 1709–1717. (IF: 7.8)
5)Yadong Zhong, Wei Huang, Jiang Du, Zekun Wang, Jianbo He, Lingfei Luo*. (2019). Improved Tol2-mediated enhancer trap identifies weakly expressed genes during liver and β cell development and regeneration in zebrafish. Journal of Biological Chemistry 294(3), 932–940. (IF: 4.1)
6)Qingliang Zou, Kai Gang, Qifen Yang, Xiaolin Liu, Xuemei Tang, Huiqiang Lu, Jianbo He, Lingfei Luo*. (2018). The CCCH-type zinc finger transcription factor Zc3h8 represses NF-kB-mediated inflammation in digestive organs in zebrafish. Journal of Biological Chemistry 293(31), 11971–11983. (IF: 4.1)
7)Chi Liu, Chuan Wu, Qifen Yang, Jing Gao, Li Li, Deqin Yang*, Lingfei Luo*. (2016). Macrophages mediate the repair of brain vascular rupture through direct physical adhesion and mechanical traction. Immunity 44(5), 1162–1176. (IF: 22.8)
8)Yuan Lin, Xuejiang Guo, Bijun Zhao, Juanjuan Liu, Min Da, Yang Wen, Yuanli Hu, Bixian Ni, Kai Zhang, Shiwei Yang, Jing Xu, Juncheng Dai, Xiaowei Wang, Yankai Xia, Hongxia Ma, Guangfu Jin, Shiqiang Yu, Jiayin Liu, Bernard D. Keavney, Judith A. Goodship, Heather J. Cordell, Xinru Wang, Hongbing Shen, Jiahao Sha, Zuomin Zhou, Yijiang Chen, Xuming Mo*, Lingfei Luo*, Zhibin Hu*. (2015). Association analysis identifies new risk loci for congenital heart disease in Chinese populations. Nature Communications 6, 8082. (IF: 11.3)
9)Jianbo He, Huiqiang Lu, Qingliang Zou, Lingfei Luo*. (2014). Regeneration of liver after extreme hepatocyte loss occurs mainly via biliary transdifferentiation in zebrafish. Gastroenterology 146(3), 789-800. (IF: 20.8,封面文章)
10)Huiqiang Lu, Jun Ma, Yun Yang, Wenchao Shi, Lingfei Luo*. (2013). EpCAM is an endoderm-specific Wnt derepressor that licenses hepatic development. Developmental Cell 24(5), 543-553. (IF: 10.4)
11)Sizhou Huang, Jun Ma, Xiaolin Liu, Yaoguang Zhang, Lingfei Luo*. (2011). Retinoic acid signaling sequentially controls visceral and heart laterality in zebrafish. Journal of Biological Chemistry 286(32), 28533-28543. (IF: 4.6)
12)Xiaolin Liu, Sizhou Huang, Jun Ma, Chun Li, Yaoguang Zhang, Lingfei Luo*. (2009). NF-κB and Snail1a coordinate the cell cycle with gastrulation. Journal of Cell Biology 184(6), 805-815. (IF: 10.4)
13)Lingfei Luo, Xiaoping Yang, Yoshihiro Takihara, Hendrik Knoetgen, Michael Kessel*. (2004). The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions. Nature 427(6976), 749-753. (IF: 38.1)
*通讯作者
实验室主要仪器设备:
分子发育生物学实验室已具备较完善的仪器平台和实验技术平台。现有主要仪器设备包括斑马鱼培养恒温洁净区、SPF动物房、4度冷库、37度恒温培养间、Aisheng和AquaticHabitats斑马鱼培养繁殖系统(40个养殖单元)、Tecniplast小鼠养殖系统(2500笼)、Zeiss Crossbeam540 FIB-SEM双束电子显微镜、Zeiss LightsheetZ1激光层照扫描显微镜、Zeiss LSM780NLO-OPO双光子显微镜、MoFlo XDP高速流式细胞分选仪、Zeiss LSM880-Airyscan激光共聚焦显微镜、Zeiss LSM780激光共聚焦显微镜、Leica SP5-AOBS正置激光共聚焦显微镜、Zeiss AxioImageZ1全自动正置荧光显微镜、Zeiss AxioObserverA1倒置荧光显微镜、Zeiss SteREO DiscoveryV20荧光体视显微镜2台、Leica M165C荧光体视显微镜7台、Zeiss体视解剖显微镜4台、Leica体视解剖显微镜3台、Leica冷冻切片机、Leica石蜡切片机、Leica振荡切片机、Elga超纯水系统、Nanodrop生物分光光度计、Eppendorf生物分光光度计、Eppendorf胚胎显微注射仪、Parker胚胎显微注射仪5台、Eppendorf细胞移植操作器Cell Tram Vario 2套、Narishige拉针仪、Narishige锻针仪、Memmert和Heraeus立式恒温胚胎培养箱5台、Bio-rad DNA和蛋白电泳及转印系统、Bio-rad凝胶成像系统、Bio-rad化学发光检测系统、Eppendorf荧光定量PCR仪、Eppendorf梯度PCR仪9台、Bio-rad梯度PCR仪、Promega荧光素报告酶检测仪、PerkinElmer磷屏扫描检测系统、立式高速(Sorvall)和桌面高速(Heraeus、Eppendorf)离心机共12台、Diagenode非接触式超声破碎仪(ChIP专用)、Heal Force细胞培养箱及细胞生物安全操作柜各2台、Ziegra制冰机、Sartorius全自动天平4台、Cole-Parmer实验室自动洗瓶机、NBS大型恒温摇床2台、NBS高速摇床、GFL高速摇床、Memmert和GFL恒温水浴锅10台、Diagenode非接触式超声破碎仪、Dr.Hielscher超声破碎仪、GE(Amersham)蛋白纯化系统、Revco超低温冰箱5台、MVE液氮存储系统、Imaris图像分析处理系统等。
实验室欢迎有志于从事脊椎动物器官发育与再生研究的学生加入(包括保送生和调剂生)。
联系方式:
电话:023-68367957
传真:023-68367958
Email: lingfeiluo@126.com