生命科学学院学术报告暨研究生招生宣讲

发布时间: 2021-05-08 16:39:42 访问量:

生命科学学院学术报告暨研究生招生宣讲

报告题目:细胞蛇(Cytoophidia: Snakes in a Cell)

报告人:刘冀珑  教授,研究员,博士生导师

报告时间:2021年5月10日上午9:30

报告地点:生命科学学院(14教学楼)224多功能学术报告厅

邀请单位:生命科学学院

报告内容摘要:

Subcellular sequestration of proteins within membrane bound compartments is widely acknowledged to be an important mode of enzymatic regulation. Recently a novel paradigm for metabolic enzyme compartmentation has become apparent with the identification of several proteins which are able to form filamentous structures in vivo. Multiple studies independently identified the essential de novo pyrimidine biosynthesis enzyme CTP synthase as a major constituent of a novel filamentous structure which has been termed “the cytoophidium”. Cytoophidia have been observed to form in three domains of life, including bacteria, archaea, and eukaryotes such as yeast, fruit fly, plants and humans. My group is investigating the biology of cytoophidia via cross-disciplinary approaches. Our study provides an important resource for an integrative understanding of the biogenesis of this novel organelle.

报告人简介:

刘冀珑 教授,研究员,博士生导师,上海科技大学生命科学与技术学院副院长。研究方向:代谢细胞生物学,细胞蛇。研究内容:1.以果蝇、酵母菌和人的培养细胞为主要研究材料探索代谢酶(如CTP合成酶和IMP脱氢酶等)在细胞里如何被区域化;2.研究不同的代谢酶如何组装成细胞蛇,以及细胞蛇和类似的细胞器如何在代谢调控和肿瘤生物学发挥作用。