孙丽娜，博士，教授，硕士生导师。西南大学动物学专业博士，美国马里兰大学访问学者。主要从事鱼类性别决定和分化机制研究、鱼类经济性状遗传解析和遗传育种研究。主持国家自然科学基金、国家重点研发计划子课题等项目多项，近年来在Molecular Ecology Resources、Zoological Research、Water Biology and Security、Aquaculture、Endocrinology等杂志发表论文40余篇，获重庆市自然科学奖三等奖1项。主讲细胞生物学、发育生物学等课程。
立足本职工作，践行初心使命
研究方向
1.鱼类性别决定与分化的分子机制和表观遗传
2.鱼类经济性状遗传解析和分子育种
联系方式
Email：sunlina233@163.com
地址：重庆市北碚区天生路1号西南大学生命科学学院 邮编：400715
代表性学术论文
#同等贡献（# equal contribution）；*通讯作者（*corresponding author）
1.Sun L, Wu Q, Cai R, Yang S, Gan L, Bai F, Gao T, Tao W, Li W*, Wang D*. 2026.Deficiency of SSTR2a promotes body growth by activating the GH/IGF axis in Nile tilapiaOreochromis niloticus. Water Biology and Security. Available online 30 June 2025, 100445.
2.Gao T, Ma S, Zhang S, Bai F, Gan L, Tao W, Wang F, Wang D*,Sun L*. 2026. Genome Expansion of ZPB1(a) and ZPC1(a) in Basal Species or Liver Expression of ZPB1a and ZPC1aa in Advanced Species, Two Different Strategies to Ensure Sufficient ZP Synthesis in Teleosts. Integrative Zoology. Online 2025.10.08.
3. Gao T, Wang F, Ma S, Bai F, Gan L, Li M, Liu X, Wang D*,Sun L*. 2025.Onychostoma macrolepis, a cyprinid fish, displays a unique pattern of temperature-dependent sex determination.Zoological Research. 46(6):1327-1338.
4.Wang F, Gao T#, Yang X, Wu Q, Li Y, Ye M, Bai F, Gan L, Wang D*,Sun L *. 2025. DNA methylation plays a critical role in testicular maintenance, but not in sex determination of male tilapiaOreochromis niloticus. Aquaculture. 595: 741455.
5.Sun L#, Gao T#, Li Z, Yang X, Qin Z, Ye M, Li Y, Wang F, Wang D*. 2025. Creation of body color mutants by CRISPRCas9 gene editing in largemouth bass. Aquaculture Reports. 40, 102593.
6.Wang F, Bai F, Gao T, Chen Y, Wu F, Xie X, Wang D*,Sun L*. 2025. Prepubertal exposure to 17β-estradiol downregulates motor protein genes, impairs sperm flagella formation, and reduces fertility in Nile tilapia (Oreochromis niloticus).Aquatic Toxicology. 285:107422.
7.Gao T, Wang F, Wu Q, Gan L, Jin C, Ma L, Wang D*,Sun L*. 2025. Mutation of Genes Associated with Body Color, Growth, Intermuscular Bone, and Sex Differentiation inOnychostoma macrolepisUsing CRISPR/Cas9. Fishes. 10(2), 40.
8.Lu B, Liang G, Xu M, Wang C, Tan D, Tao W,Sun L *, Wang D *. 2022. Production of all male amelanotic red tilapia by combining MAS-GMT andtyrbmutation. Aquaculture.546,737327.
9.Qin Z, Li Z, Yang S, Wang F, Gao T, Tao W, Zhou L, Wang D*,Sun L*. 2022. Genome-wide identification, evolution of histone lysine demethylases (KDM) genes and their expression during gonadal development in Nile tilapia. Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology. 257:110674.
10.Lu B, Wang C, Liang G, Xu M, Kocher T,Sun L*, Wang D*. 2022. Generation of ornamental Nile tilapia with distinct gray and black body color pattern bycsf1ramutation. Aquaculture Reports.23, 101077.
11.Wang F, Qin Z, Li Z, Yang S, Gao T,Sun L*, Wang D*. 2021. Dnmt3aa but not dnmt3ab is required for maintenance of gametogenesis in Nile tilapia (Oreochromis niloticus). International Journal of Molecular Sciences. 22(18):10170-10188.
12.Sun L,Gao T,Wang F,Qin Z,Yan L,Tao W,Li M,Jin C,Ma L,Kocher T,Wang D*. Chromosome-level genome assembly of a cyprinid fishOnychostoma macrolepisby integration of Nanopore Sequencing, Bionano and Hi-C technology. Molecular Ecology Resources. 20:1361-1371.
13.Yan L, Feng H, Wang F, Lu B, Liu X,Sun L*, Wang D*. 2019. Establishment of three estrogen receptors (esr1,esr2a,esr2b) knockout lines for functional study in Nile tilapia. Journal of Steroid Biochemistry and Molecular Biology. 191: 105379.
14.Wang F, Yan L, Shi H, Liu X, Zheng Q,Sun L*, Wang D*. 2018. Genome-wide identification, evolution of DNA methyltransferases and their expression during gonadal development in Nile tilapia. Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology. 226:73-84.
15. Shi H#, Gao T#, Liu Z#,Sun L#, Jiang X, Chen L, Wang D*. 2017. Blockage of androgen and administration of estrogen induce transdifferentiation of testis into ovary.Journal of Endocrinology. 233(1):65-80.
16.Tao W#,Sun L#, Shi H, Cheng Y, Jiang D, Fu B, Conte MA, Gammerdinger WJ, Kocher TD, Wang D*. 2016. Integrated analysis of miRNA and mRNA expression profiles in tilapia gonads at an early stage of sex differentiation. BMC Genomics. 17(1):328.
17.Sun L, Jiang X, Xie Q, Yuan J, Huang B, Tao W, Zhou L, Nagahama Y, Wang D*. 2014. Transdifferentiation of differentiated ovary into functional testis by long term treatment of aromatase inhibitor in Nile tilapia. Endocrinology. 155(4):1476-1488.
18.Tao W#, Yuan J#, Zhou L#,Sun L#, Sun Y, Yang S, Li M, Zeng S, Huang B,Wang D*. Characterization of gonadal transcriptomes from Nile tilapia (Oreochromis niloticus) reveals differentially expressed genes. PLoS One. 8: e63604.
